N-Acetylcysteine MATRIS® TM
Technical data sheet
Taste Masking (TM)
Ensures greater treatment adherence and user compliance by masking the taste and odor of unpleasant ingredients.
Gastric Protection (GP)
Provides gastric protection to minimize gastric wall sensitization and ensures active ingredients are delivered intact through the gastric tract to the intestine.
Free Flowing (FF)
Enhances product flowability in processing lines, significantly reducing the risk of caking and lump formation.
Timed Release (TR)
Utilizes advanced technology to achieve controlled, prolonged release, ensuring enhanced availability, absorption, and effectiveness of the product.
Improved Availability (IB)
Enhances product availability by ensuring uniform and rapid distribution along the gastro-enteric tract, maximizing active ingredient absorption.
Taste Masking (TM)
Ensures greater treatment adherence...
Gastric Protection (GP)
Provides gastric protection to minimize gastric...
Free Flowing (FF)
Enhances product flowability in processing lines...
Timed Release (TR)
Utilizes advanced technology to...
Improved Availability (IB)
Enhances product availability by ensuring uniform...
Microencapsulated N-Acetylcysteine for food supplements
N-acetylcysteine (NAC) is on the World Health Organization’s list of essential medicines, the most effective and safe medicines needed in a health system.[1]
This active ingredient is used for the treatment of Paracetamol (Acetaminophen) overdose[2] and, as a mucolytic, for its mucus dissolving properties.[3]
Acetylcysteine is also widely used as a dietary supplement with antioxidant and liver protecting effects.
It has a very unpleasant taste of sulphur.
Adverse effects for oral formulations have been reported to include nausea and vomit.[4]
The MATRISâ formulation provides a total covering of such disagreeable taste, making the administration of tablets (also divisible) and single dose sachets (also oro-dispersible) easier (better patient compliance),primarily for pediatric use.
N-Acetylcysteine Coated with a polymeric membrane
The M.A.T.R.I.S.® form, thanks to the particular characteristics of fine and flowable particle size, allows the active substances to spread in a quick and uniform way on the whole surface of the gastro-intestinal tract, starting the modified release at the stomach and/or intestine level, according to the properties of the used membranes.
Eliminating the need of inner inert cores, makes it possible to attain a high concentration of the active ingredients, suitable for the manufacture of the final dosage form envisaged.
The novel form of the active ingredients so obtained, enables the production of different final dosage forms of administration, with an active substance title much higher (up to 80%) than the conventional microgranules, pellets, tablets and minitablets.
Such forms are high dosage tablets and capsules, single dose sachets, both dispersible and oro-soluble, single dose bottles with metering stoppers, impossible to obtain with the traditional coating processes (granules for hard gelatin capsules and traditional tablets), thus allowing final administration forms with better possibility to add other active ingredients.
The M.A.T.R.I.S.® process is carried on in compliance with cGMP for food supplements.
All batches are provided with certificate of analysis.
BIBLIOGRAPHY
[1] “WHO Model List of Essential Medicines (19th List)”
[2] Green JL , Heard KJ, Reynolds KM, Albert D (May 2013). “Oral and Intravenous Acetylcysteine for Treatment of Aceteminophen Toxicity: A Sistematic Review and Meta-analysis”
[3] “Acetylcysteine” (http://w.drugs.com/monograph/acetylcysteine.html)
[4] “Mucomyst Package Insert” (http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d2dc24f3-3ad7-4c6c-8e9f-7202d9a146f7).
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