Melatonin is a hormone known for its crucial role in regulating the body’s circadian rhythms, essential for managing natural sleep and wake cycles. Traditionally used as a supplement to improve sleep quality, melatonin presents some challenges, such as the difficulty in maintaining stable hormonal levels throughout the night, which can limit its effectiveness.
The Role of Melatonin in Sleep
Melatonin is naturally produced by the pineal gland in response to darkness, helping the body prepare for sleep. However, its secretion decreases with age and can be negatively influenced by various factors such as stress, travel, exposure to artificial light, and irregular sleep cycles. These disruptions can lead to reduced sleep quality and circadian rhythm disorders.
Melatonin Miniactives®: Innovation in Melatonin Release
IPS International Products & Services S.r.l. has developed Melatonin Miniactives® RETARD, a cutting-edge product that uses patented technology for a prolonged and modulated release of the active ingredient for up to 6 hours. This overnight release profile ensures an hourly calibrated dosage, overcoming the limitations of a high dosage that can induce sleep but not maintain it effectively throughout the night.
Studies and Research Collaborations
IPS is actively involved in collaborations with universities and private laboratories to verify the efficacy of its nutraceutical ingredients. Recently, studies on 3D organoid systems have demonstrated that some of the patented technologies by IPS are responsible for improving the kinetics of absorption of certain actives, extending their half-life, and showing superiority in absorption compared to basic ingredients. In all cases studied, there was a significant reduction in inflammation and sensitization at the gastric and intestinal levels, revealing synergistic effects on the intended therapeutic activity.
Formulations and Applications
The MINIACTIVES® technology is applied to ingredients intended for various dosage forms, such as tablets, sachets, stick packs, capsules, and bottles with dosing caps, offering several options to meet the needs of companies in the sector. Melatonin Miniactives® RETARD, available in various titrations, ensures broad formulation flexibility capable of satisfying a wide spectrum of applications. For formulas intended for direct compression, IPS also offers SmarTTabs® formulations, which preserve the original release profile of the active ingredients of the bulk product.
Conclusion
Melatonin Miniactives® RETARD represents a significant innovation in the field of dietary supplements, significantly improving sleep management and the quality of life of users. With its advanced patented technology, IPS continues to be at the forefront of nutraceutical innovation, providing effective solutions that meet the complex needs of the modern market.
Note: This article is provided for informational purposes only and does not substitute for professional medical advice.
